Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. The patient, Ramon Silva, refuses to undergo the prescribed treatment, and the team learns that after his daughter’s cancer was cured, he pledged an oath of self-sacrifice to God. With little time to save Ramon’s life, the team struggles to understand his reasoning and seemingly extreme religious convictions, but eventually learn that faith is not an argument.

Meanwhile, Taub questions his wife Rachel about her relationship with an infidelity support group member and the team attends a co-worker’s wedding where Wilson’s relationship with Sam (guest star Watros) takes an unexpected turn in the all-new “Small Sacrifices” episode of HOUSE airing Monday, Nov. 22 (8:00-9:00 PM ET/PT) on FOX 50. (HOU-708) (TV-14 D, L)

Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Robert Sean Leonard as Dr. James Wilson; Omar Epps as Dr. Eric Foreman; Jesse Spencer as Dr. Robert Chase; Olivia Wilde as Thirteen/Dr. Remy Hadley; Peter Jacobson as Dr. Chris Taub

Guest Cast: Amber Tamblyn as Martha Masters; Cynthia Watros as Sam Carr; Jennifer Crystal Foley as Rachel Taub; Madalyn Horcher as Marisa; Kuno Becker as Ramon; Jaime Zevallos as Marcus; Alan Marco as Victor; Kayla Ewell as Nika; Stella Maeve as Kenzie; Nigel Gibbs as Sanford Wells; Kirby Griffin as Casey; Ed Williams as Anthony; Bobbin Bergstrom as Nurse