After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl’s palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control’s Dr. Dave Broda (guest star Dylan Baker) institutes a lockdown on the hospital and suspends House’s team’s ability to diagnose, Masters (guest star Amber Tamblyn) grows suspicious of Broda’s motives and becomes convinced that the patient is suffering from a different disease. The girl’s father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in jeopardy. Meanwhile, Wilson and Sam (guest star Cynthia Watros) comfort a 6-year-old chemotherapy patient who prompts them to examine their relationship in the all-new “A Pox On Our House” episode of HOUSE airing Monday, Nov. 15 (8:00-9:00 PM) on FOX 50. (HOU-707) (TV-14 D, L)

Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Robert Sean Leonard as Dr. James Wilson; Omar Epps as Dr. Eric Foreman; Jesse Spencer as Dr. Robert Chase; Olivia Wilde as Thirteen/Dr. Remy Hadley; Peter Jacobson as Dr. Chris Taub

Guest Cast: Amber Tamblyn as Martha Masters; Cynthia Watros as Sam Carr; Dylan Baker as Dr. Dave Broda, Hayley Chase as Julie; Samantha Smith as Lulu; Andrew Fiscella as Niles; Aaron Refvem as Roger; Devon Woods as Eve; Leslie Murphy as Natalie; Tess Kartel as Geerte; Neil Sandilands as Captain Vanderhoof; Daniel Colembie as Dr. Trimingham; Demetrius Grosse as Hacinte; Elijah Montgomery as Ebo; Bobbin Bergstrom as Nurse